@ARTICLE{TreeBASE2Ref21971,
author = {Shannon M Hedtke and Matt J Morgan and David C. Cannatella and David M Hillis},
title = {Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time},
year = {2013},
keywords = {phylogenetics; phylogenomics; targeted enrichment; Frogs; Anura; next-generation sequencing},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS ONE},
volume = {},
number = {},
pages = {},
abstract = {Estimated phylogenies of evolutionarily diverse taxa will be well supported and more likely to be historically accurate when the analysis contains large amounts of data?many genes sequenced across many taxa. Inferring such phylogenies for non-model organisms is challenging given limited resources for whole-genome sequencing. We take advantage of genomic data from a single species to test the limits of hybridization-based enrichment of hundreds of exons across frog species that diverged up to 250 million years ago. Enrichment success for a given species depends greatly on the divergence time between it and the reference species, and the resulting alignment contains a significant proportion of missing data. However, our alignment generates a well-supported phylogeny of frogs, suggesting this technique is a practical solution towards resolving relationships across deep evolutionary time.}
}
Citation for Study 14191
Citation title:
"Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time".
Study name:
"Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time".
This study is part of submission 14191
(Status: Published).
Citation
Hedtke S.M., Morgan M.J., Cannatella D., & Hillis D.M. 2013. Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time. PLoS ONE, .
Authors
-
Hedtke S.M.
(submitter)
-
Morgan M.J.
-
Cannatella D.
-
Hillis D.M.
512-471-5792
Abstract
Estimated phylogenies of evolutionarily diverse taxa will be well supported and more likely to be historically accurate when the analysis contains large amounts of data?many genes sequenced across many taxa. Inferring such phylogenies for non-model organisms is challenging given limited resources for whole-genome sequencing. We take advantage of genomic data from a single species to test the limits of hybridization-based enrichment of hundreds of exons across frog species that diverged up to 250 million years ago. Enrichment success for a given species depends greatly on the divergence time between it and the reference species, and the resulting alignment contains a significant proportion of missing data. However, our alignment generates a well-supported phylogeny of frogs, suggesting this technique is a practical solution towards resolving relationships across deep evolutionary time.
Keywords
phylogenetics; phylogenomics; targeted enrichment; Frogs; Anura; next-generation sequencing
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S14191
- Other versions:
Nexus
NeXML
- Show BibTeX reference
@ARTICLE{TreeBASE2Ref21971,
author = {Shannon M Hedtke and Matt J Morgan and David C. Cannatella and David M Hillis},
title = {Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time},
year = {2013},
keywords = {phylogenetics; phylogenomics; targeted enrichment; Frogs; Anura; next-generation sequencing},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS ONE},
volume = {},
number = {},
pages = {},
abstract = {Estimated phylogenies of evolutionarily diverse taxa will be well supported and more likely to be historically accurate when the analysis contains large amounts of data?many genes sequenced across many taxa. Inferring such phylogenies for non-model organisms is challenging given limited resources for whole-genome sequencing. We take advantage of genomic data from a single species to test the limits of hybridization-based enrichment of hundreds of exons across frog species that diverged up to 250 million years ago. Enrichment success for a given species depends greatly on the divergence time between it and the reference species, and the resulting alignment contains a significant proportion of missing data. However, our alignment generates a well-supported phylogeny of frogs, suggesting this technique is a practical solution towards resolving relationships across deep evolutionary time.}
}
- Show RIS reference
TY - JOUR
ID - 21971
AU - Hedtke,Shannon M
AU - Morgan,Matt J
AU - Cannatella,David C.
AU - Hillis,David M
T1 - Targeted enrichment: maximizing orthologous gene comparisons across deep evolutionary time
PY - 2013
KW - phylogenetics; phylogenomics; targeted enrichment; Frogs; Anura; next-generation sequencing
UR - http://dx.doi.org/
N2 - Estimated phylogenies of evolutionarily diverse taxa will be well supported and more likely to be historically accurate when the analysis contains large amounts of data?many genes sequenced across many taxa. Inferring such phylogenies for non-model organisms is challenging given limited resources for whole-genome sequencing. We take advantage of genomic data from a single species to test the limits of hybridization-based enrichment of hundreds of exons across frog species that diverged up to 250 million years ago. Enrichment success for a given species depends greatly on the divergence time between it and the reference species, and the resulting alignment contains a significant proportion of missing data. However, our alignment generates a well-supported phylogeny of frogs, suggesting this technique is a practical solution towards resolving relationships across deep evolutionary time.
L3 -
JF - PLoS ONE
VL -
IS -
ER -
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