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Citation for Study 15636

Citation title: "The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group.".

Study name: "The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group.".

This study is part of submission 15636 (Status: Published).

Citation

Vogeler S., Galloway T.S., Lyons B.P., & Bean T.P. 2014. The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group. BMC Genomics, 15: 369.

Authors

• Vogeler S. (submitter) 00447500868833
• Galloway T.S.
• Lyons B.P.
• Bean T.P.

Abstract

Nuclear receptors are a superfamily of transcription factors important in key biological, developmental and reproductive processes. Several of these receptors are ligand- activated and through their ability to bind endogenous and exogenous ligands, are potentially vulnerable to xenobiotics. Molluscs are key ecological species in defining aquatic and terrestrial habitats and are sensitive to xenobiotic compounds in the environment. However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited. Here, forty-three nuclear receptor sequences were mined from the genome of the Pacific oyster, Crassostrea gigas. They include members of NR0-NR5 subfamilies, notably lacking any NR6 members. Phylogenetic analyses of the oyster nuclear receptors have been conducted showing the presence of a large novel subfamily group not previously reported, which is named NR1P. Homologues to all previous identified nuclear receptors in other mollusc species have also been determined including the putative heterodimer partner retinoid X receptor, estrogen receptor and estrogen related receptor. C. gigas contains a highly diverse set of nuclear receptors including a novel NR1 group, which provides important information on presence and evolution of this transcription factor superfamily in invertebrates. The Pacific oyster possesses two members of NR3, the sex steroid hormone receptor analogues, of which there are 9 in humans. This provides increasing evidence that steroid ligand specific expansion of this family is deuterostome specific. This new knowledge on divergence and emergence of nuclear receptors in C. gigas provides essential information for studying regulation of molluscan gene expression and the potential effects of xenobiotics.

Keywords

Mollusc, hormone receptor, bivalve, xenobiotics, transcription factor

External links

• DOI: 10.1186/1471-2164-15-369

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S15636
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref23065,
  	 author = {Susanne  Vogeler and Tamara S Galloway and Brett P Lyons and Tim P Bean},
  	 title = {The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group.},
  	 year = {2014},
  	 keywords = {Mollusc, hormone receptor, bivalve, xenobiotics, transcription factor},
  	 doi = {10.1186/1471-2164-15-369},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC Genomics},
  	 volume = {15},
  	 number = {},
  	 pages = {369},
  	 abstract = {Nuclear receptors are a superfamily of transcription factors important in key biological, developmental and reproductive processes. Several of these receptors are ligand- activated and through their ability to bind endogenous and exogenous ligands, are potentially vulnerable to xenobiotics. Molluscs are key ecological species in defining aquatic and terrestrial habitats and are sensitive to xenobiotic compounds in the environment. However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited.
  Here, forty-three nuclear receptor sequences were mined from the genome of the Pacific oyster, Crassostrea gigas. They include members of NR0-NR5 subfamilies, notably lacking any NR6 members. Phylogenetic analyses of the oyster nuclear receptors have been conducted showing the presence of a large novel subfamily group not previously reported, which is named NR1P. Homologues to all previous identified nuclear receptors in other mollusc species have also been determined including the putative heterodimer partner retinoid X receptor, estrogen receptor and estrogen related receptor.
  C. gigas contains a highly diverse set of nuclear receptors including a novel NR1 group, which provides important information on presence and evolution of this transcription factor superfamily in invertebrates. The Pacific oyster possesses two members of NR3, the sex steroid hormone receptor analogues, of which there are 9 in humans. This provides increasing evidence that steroid ligand specific expansion of this family is deuterostome specific. This new knowledge on divergence and emergence of nuclear receptors in C. gigas provides essential information for studying regulation of molluscan gene expression and the potential effects of xenobiotics.
  }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 23065
  AU  - Vogeler,Susanne 
  AU  - Galloway,Tamara S
  AU  - Lyons,Brett P
  AU  - Bean,Tim P
  T1  - The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group.
  PY  - 2014
  KW  - Mollusc
  KW  - hormone receptor
  KW  - bivalve
  KW  - xenobiotics
  KW  - transcription factor
  UR  - http://dx.doi.org/10.1186/1471-2164-15-369
  N2  - Nuclear receptors are a superfamily of transcription factors important in key biological, developmental and reproductive processes. Several of these receptors are ligand- activated and through their ability to bind endogenous and exogenous ligands, are potentially vulnerable to xenobiotics. Molluscs are key ecological species in defining aquatic and terrestrial habitats and are sensitive to xenobiotic compounds in the environment. However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited.
  Here, forty-three nuclear receptor sequences were mined from the genome of the Pacific oyster, Crassostrea gigas. They include members of NR0-NR5 subfamilies, notably lacking any NR6 members. Phylogenetic analyses of the oyster nuclear receptors have been conducted showing the presence of a large novel subfamily group not previously reported, which is named NR1P. Homologues to all previous identified nuclear receptors in other mollusc species have also been determined including the putative heterodimer partner retinoid X receptor, estrogen receptor and estrogen related receptor.
  C. gigas contains a highly diverse set of nuclear receptors including a novel NR1 group, which provides important information on presence and evolution of this transcription factor superfamily in invertebrates. The Pacific oyster possesses two members of NR3, the sex steroid hormone receptor analogues, of which there are 9 in humans. This provides increasing evidence that steroid ligand specific expansion of this family is deuterostome specific. This new knowledge on divergence and emergence of nuclear receptors in C. gigas provides essential information for studying regulation of molluscan gene expression and the potential effects of xenobiotics.
  
  L3  - 10.1186/1471-2164-15-369
  JF  - BMC Genomics
  VL  - 15
  IS  - 
  ER  -