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Citation for Study 15721

Citation title: "Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity ".

Study name: "Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity ".

This study is part of submission 15721 (Status: Published).

Citation

Vicens A., Tourmente M., & Roldan E.R. 2014. Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity. BMC EVolutionary Biology, .

Authors

• Vicens A.
• Tourmente M.
• Roldan E.R.

Abstract

Background: Competition between spermatozoa from rival males for success in fertilization (i.e., sperm competition) is an important selective force driving the evolution of male reproductive traits and promoting positive selection in genes related to reproductive function. Positive selection has been identified in reproductive proteins showing rapid divergence at nucleotide level. Other mutations, such as insertions and deletions (indels), also occur in protein-coding sequences. These structural changes, which exist in reproductive genes and result in length variation in coded proteins, could also be subjected to positive selection and be under the influence of sperm competition. Catsper1 is one such reproductive gene coding for a germ-line specific voltage-gated calcium channel essential for sperm motility and fertilization. Positive selection appears to promote fixation of indels in the N-terminal region of CatSper1 in mammalian species. However, it is not known which selective forces underlie these changes and their implications for sperm function. Results: We tested if length variation in the N-terminal region of CatSper1 is influenced by sperm competition intensity in a group of closely related rodent species of the subfamily Murinae. Our results revealed a negative correlation between sequence length of CatSper1 and relative testes mass, a very good proxy of sperm competition levels. Since CatSper1 is important for sperm flagellar motility, we examined if length variation in the N-terminus of CatSper1 is linked to changes in sperm swimming velocity. We found a negative correlation between CatSper1 length and several sperm velocity parameters. Conclusions: Altogether, our results suggest that sperm competition selects for a shortening of the intracellular region of CatSper1 which, in turn, enhances sperm swimming velocity, an essential and adaptive trait for fertilization success.

Keywords

CatSper1, sperm competition, indels, positive selection, sperm velocity, rodents.

External links

• Other URL: http://www.biomedcentral.com/author/manuscript/details/view.do?txt_nav=man&txt_man_id=9053079911872469&manuscriptId=9053079911872469

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S15721
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref23135,
  	 author = {Alberto  Vicens and Maximiliano  Tourmente and Eduardo RS Roldan},
  	 title = {Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity },
  	 year = {2014},
  	 keywords = {CatSper1, sperm competition, indels, positive selection, sperm velocity, rodents.},
  	 doi = {},
  	 url = {http://www.biomedcentral.com/author/manuscript/details/view.do?txt_nav=man&txt_man_id=9053079911872469&manuscriptId=9053079911872469 },
  	 pmid = {},
  	 journal = {BMC EVolutionary Biology},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Background:  Competition between spermatozoa from rival males for success in fertilization (i.e., sperm competition) is an important selective force driving the evolution of male reproductive traits and promoting positive selection in genes related to reproductive function. Positive selection has been identified in reproductive proteins showing rapid divergence at nucleotide level. Other mutations, such as insertions and deletions (indels), also occur in protein-coding sequences. These structural changes, which exist in reproductive genes and result in length variation in coded proteins, could also be subjected to positive selection and be under the influence of sperm competition. Catsper1 is one such reproductive gene coding for a germ-line specific voltage-gated calcium channel essential for sperm motility and fertilization. Positive selection appears to promote fixation of indels in the N-terminal region of CatSper1 in mammalian species. However, it is not known which selective forces underlie these changes and their implications for sperm function.
  Results:  We tested if length variation in the N-terminal region of CatSper1 is influenced by sperm competition intensity in a group of closely related rodent species of the subfamily Murinae. Our results revealed a negative correlation between sequence length of CatSper1 and relative testes mass, a very good proxy of sperm competition levels. Since CatSper1 is important for sperm flagellar motility, we examined if length variation in the N-terminus of CatSper1 is linked to changes in sperm swimming velocity. We found a negative correlation between CatSper1 length and several sperm velocity parameters. 
  Conclusions:  Altogether, our results suggest that sperm competition selects for a shortening of the intracellular region of CatSper1 which, in turn, enhances sperm swimming velocity, an essential and adaptive trait for fertilization success.
  }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 23135
  AU  - Vicens,Alberto 
  AU  - Tourmente,Maximiliano 
  AU  - Roldan,Eduardo RS
  T1  - Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity 
  PY  - 2014
  KW  - CatSper1
  KW  - sperm competition
  KW  - indels
  KW  - positive selection
  KW  - sperm velocity
  KW  - rodents.
  UR  - http://www.biomedcentral.com/author/manuscript/details/view.do?txt_nav=man&txt_man_id=9053079911872469&manuscriptId=9053079911872469 
  N2  - Background:  Competition between spermatozoa from rival males for success in fertilization (i.e., sperm competition) is an important selective force driving the evolution of male reproductive traits and promoting positive selection in genes related to reproductive function. Positive selection has been identified in reproductive proteins showing rapid divergence at nucleotide level. Other mutations, such as insertions and deletions (indels), also occur in protein-coding sequences. These structural changes, which exist in reproductive genes and result in length variation in coded proteins, could also be subjected to positive selection and be under the influence of sperm competition. Catsper1 is one such reproductive gene coding for a germ-line specific voltage-gated calcium channel essential for sperm motility and fertilization. Positive selection appears to promote fixation of indels in the N-terminal region of CatSper1 in mammalian species. However, it is not known which selective forces underlie these changes and their implications for sperm function.
  Results:  We tested if length variation in the N-terminal region of CatSper1 is influenced by sperm competition intensity in a group of closely related rodent species of the subfamily Murinae. Our results revealed a negative correlation between sequence length of CatSper1 and relative testes mass, a very good proxy of sperm competition levels. Since CatSper1 is important for sperm flagellar motility, we examined if length variation in the N-terminus of CatSper1 is linked to changes in sperm swimming velocity. We found a negative correlation between CatSper1 length and several sperm velocity parameters. 
  Conclusions:  Altogether, our results suggest that sperm competition selects for a shortening of the intracellular region of CatSper1 which, in turn, enhances sperm swimming velocity, an essential and adaptive trait for fertilization success.
  
  L3  - 
  JF  - BMC EVolutionary Biology
  VL  - 
  IS  - 
  ER  -