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Citation for Study 16248

Citation title: "Overlapping genes: a window on gene evolvability.".

Study name: "Overlapping genes: a window on gene evolvability.".

This study is part of submission 16248 (Status: Published).

Citation

Huvet M., & Stumpf M.P. 2014. Overlapping genes: a window on gene evolvability. BMC genomics, .

Authors

• Huvet M. (submitter)
• Stumpf M.P.

Abstract

Background The forces underlying genome architecture and organization are still only poorly understood in detail. Overlapping genes (genes partially or entirely overlapping) represent a genomic feature that is shared widely between biological organisms ranging from viruses to multi-cellular organisms. In bacteria, a third of the annotated genes are involved in an overlap. Despite the widespread nature of this arrangement, its evolutionary origins and biological ramifications have so far eluded explanation. Results Here we present a comparative approach using information from 699 bacterial genomes that sheds light on the evolutionary dynamics of overlapping genes. We show that these structures exhibit high levels of plasticity. Conclusions We propose a simple model allowing us to explain the observed properties of overlapping genes based on the importance of initiation and termination of transcriptional and translational processes. We believe that taking into account the processes leading to the expression of protein-coding genes hold the key to the understanding of overlapping genes structures.

Keywords

Overlapping genes, evolution, expression regulation, operon

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S16248
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref23553,
  	 author = {maxime  huvet and Michael P.H Stumpf},
  	 title = {Overlapping genes: a window on gene evolvability.},
  	 year = {2014},
  	 keywords = {Overlapping genes, evolution, expression regulation, operon},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC genomics},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Background
  The forces underlying genome architecture and organization are still only poorly
  understood in detail. Overlapping genes (genes partially or entirely overlapping) represent
  a genomic feature that is shared widely between biological organisms ranging from viruses
  to multi-cellular organisms. In bacteria, a third of the annotated genes are involved in an
  overlap. Despite the widespread nature of this arrangement, its evolutionary origins and
  biological ramifications have so far eluded explanation.
  Results
  Here we present a comparative approach using information from 699 bacterial genomes
  that sheds light on the evolutionary dynamics of overlapping genes. We show that these
  structures exhibit high levels of plasticity.
  Conclusions
  We propose a simple model allowing us to explain the observed properties of overlapping
  genes based on the importance of initiation and termination of transcriptional and
  translational processes. We believe that taking into account the processes leading to the
  expression of protein-coding genes hold the key to the understanding of overlapping
  genes structures.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 23553
  AU  - huvet,maxime 
  AU  - Stumpf,Michael P.H
  T1  - Overlapping genes: a window on gene evolvability.
  PY  - 2014
  KW  - Overlapping genes
  KW  - evolution
  KW  - expression regulation
  KW  - operon
  UR  - http://dx.doi.org/
  N2  - Background
  The forces underlying genome architecture and organization are still only poorly
  understood in detail. Overlapping genes (genes partially or entirely overlapping) represent
  a genomic feature that is shared widely between biological organisms ranging from viruses
  to multi-cellular organisms. In bacteria, a third of the annotated genes are involved in an
  overlap. Despite the widespread nature of this arrangement, its evolutionary origins and
  biological ramifications have so far eluded explanation.
  Results
  Here we present a comparative approach using information from 699 bacterial genomes
  that sheds light on the evolutionary dynamics of overlapping genes. We show that these
  structures exhibit high levels of plasticity.
  Conclusions
  We propose a simple model allowing us to explain the observed properties of overlapping
  genes based on the importance of initiation and termination of transcriptional and
  translational processes. We believe that taking into account the processes leading to the
  expression of protein-coding genes hold the key to the understanding of overlapping
  genes structures.
  L3  - 
  JF  - BMC genomics
  VL  - 
  IS  - 
  ER  -