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Citation for Study 18159

Citation title: "Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte".

Study name: "Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte".

This study is part of submission 18159 (Status: Published).

Citation

Forcina G.C., Castro A., Bokesch H.R., Spakowicz D.J., Legaspi M.E., Kucera K., Villota S., Narvaez-trujillo A., Mcmahon J.B., Gustafson K.R., & Strobel S.A. 2015. Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte. Journal of Natural Products, .

Authors

Forcina G.C.
Castro A.
Bokesch H.R.
Spakowicz D.J.
Legaspi M.E.
Kucera K.
Villota S.
Narvaez-trujillo A.
Mcmahon J.B.
Gustafson K.R.
Strobel S.A.

Abstract

Endophytic fungi are plant tissue-associated fungi that represent a rich resource of unexplored biological and chemical diversity. As part of an ongoing effort to characterize Amazon rainforest-derived endophytes, numerous fungi were isolated and cultured from plants collected in the Yasuni National Park in Ecuador. Of these samples, phylogenetic and morphological data revealed a previously undescribed fungus in the order Pleosporales that was cultured from the tropical tree Duroia hirsuta. Extracts from this fungal isolate displayed activity against Staphylococcus aureus and were thus subjected to detailed chemical studies. Two compounds with modest antibacterial activity were isolated and their structures were elucidated using a combination of NMR spectroscopic analysis, LC-MS studies, and chemical degradation. These efforts led to the identification of stelliosphaerols A (1) and B (2), new sesquiterpene-polyol conjugates that are responsible, at least in part, for the S. aureus inhibitory activity of the fungal extract.

External links

DOI: 10.1021/acs.jnatprod.5b00749

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S18159
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref25374,
	 author = {Giovanni Charles Forcina and Amaya  Castro and Heidi R Bokesch and Daniel J Spakowicz and Michelle E Legaspi and Kaury  Kucera and Stephany  Villota and Alexandra  Narvaez-Trujillo and James B McMahon and Kirk R Gustafson and Scott A Strobel},
	 title = {Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte},
	 year = {2015},
	 keywords = {},
	 doi = {10.1021/acs.jnatprod.5b00749},
	 url = {http://},
	 pmid = {},
	 journal = {Journal of Natural Products},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {Endophytic fungi are plant tissue-associated fungi that represent a rich resource of unexplored biological and chemical diversity. As part of an ongoing effort to characterize Amazon rainforest-derived endophytes, numerous fungi were isolated and cultured from plants collected in the Yasuni National Park in Ecuador. Of these samples, phylogenetic and morphological data revealed a previously undescribed fungus in the order Pleosporales that was cultured from the tropical tree Duroia hirsuta. Extracts from this fungal isolate displayed activity against Staphylococcus aureus and were thus subjected to detailed chemical studies. Two compounds with modest antibacterial activity were isolated and their structures were elucidated using a combination of NMR spectroscopic analysis, LC-MS studies, and chemical degradation. These efforts led to the identification of stelliosphaerols A (1) and B (2), new sesquiterpene-polyol conjugates that are responsible, at least in part, for the S. aureus inhibitory activity of the fungal extract. }
}

Show RIS reference

		TY  - JOUR
ID  - 25374
AU  - Forcina,Giovanni Charles
AU  - Castro,Amaya 
AU  - Bokesch,Heidi R
AU  - Spakowicz,Daniel J
AU  - Legaspi,Michelle E
AU  - Kucera,Kaury 
AU  - Villota,Stephany 
AU  - Narvaez-Trujillo,Alexandra 
AU  - McMahon,James B
AU  - Gustafson,Kirk R
AU  - Strobel,Scott A
T1  - Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte
PY  - 2015
KW  - 
UR  - http://dx.doi.org/10.1021/acs.jnatprod.5b00749
N2  - Endophytic fungi are plant tissue-associated fungi that represent a rich resource of unexplored biological and chemical diversity. As part of an ongoing effort to characterize Amazon rainforest-derived endophytes, numerous fungi were isolated and cultured from plants collected in the Yasuni National Park in Ecuador. Of these samples, phylogenetic and morphological data revealed a previously undescribed fungus in the order Pleosporales that was cultured from the tropical tree Duroia hirsuta. Extracts from this fungal isolate displayed activity against Staphylococcus aureus and were thus subjected to detailed chemical studies. Two compounds with modest antibacterial activity were isolated and their structures were elucidated using a combination of NMR spectroscopic analysis, LC-MS studies, and chemical degradation. These efforts led to the identification of stelliosphaerols A (1) and B (2), new sesquiterpene-polyol conjugates that are responsible, at least in part, for the S. aureus inhibitory activity of the fungal extract. 
L3  - 10.1021/acs.jnatprod.5b00749
JF  - Journal of Natural Products
VL  - 
IS  - 
ER  -