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Citation for Study 19540

Citation title: "Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.".

Study name: "Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.".

This study is part of submission 19540 (Status: Published).

Citation

Clop A., Sharaf A., Castell? A., Ramos-onsins S.E., Cirera S., Mercad? A., Derdak S., Beltran S., Huisman A., Fredholm M., Van as P., & S?nchez A. 2016. Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes. BMC Genomics, .

Authors

• Clop A.
• Sharaf A.
• Castell? A.
• Ramos-onsins S.E. (submitter) +34935636600
• Cirera S.
• Mercad? A.
• Derdak S.
• Beltran S.
• Huisman A.
• Fredholm M.
• Van as P.
• S?nchez A.

Abstract

Taste receptors (TASRs) are essential for the body?s recognition of chemical compounds. In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour. Moreover, their relevance in other organs is now becoming evident. In the intestine, they regulate nutrient absorption and gut motility. Upon ligand binding, TASRs activate the appetite-reward circuitry to signal the nervous system and keep body homeostasis. With the aim to identify genetic variation in the swine TASRs and in the genes from the appetite and the reward pathways, we have sequenced the exons of 201 TASRs and appetite-reward genes from 304 pigs belonging to ten breeds and to two phenotypically extreme groups from a F2 resource with data on growth and fat deposition.

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S19540
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref26078,
  	 author = {Alex  Clop and Abdoallah  Sharaf and Anna  Castell? and Sebastian E. Ramos-Onsins and Susanna  Cirera and Anna  Mercad? and Sophia  Derdak and Sergi  Beltran and Abe  Huisman and Merete  Fredholm and Pieter  van As and Armand  S?nchez},
  	 title = {Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.},
  	 year = {2016},
  	 keywords = {},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC Genomics},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Taste receptors (TASRs) are essential for the body?s recognition of chemical compounds.  In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour.  Moreover, their relevance in other organs is now becoming evident.  In the intestine, they regulate nutrient absorption and gut motility.  Upon ligand binding, TASRs activate the appetite-reward circuitry to signal the nervous system and keep body homeostasis.  With the aim to identify genetic variation in the swine TASRs and in the genes from the appetite and the reward pathways, we have sequenced the exons of 201 TASRs and appetite-reward genes from 304 pigs belonging to ten breeds and to two phenotypically extreme groups from a F2 resource with data on growth and fat deposition.  }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 26078
  AU  - Clop,Alex 
  AU  - Sharaf,Abdoallah 
  AU  - Castell?,Anna 
  AU  - Ramos-Onsins,Sebastian E.
  AU  - Cirera,Susanna 
  AU  - Mercad?,Anna 
  AU  - Derdak,Sophia 
  AU  - Beltran,Sergi 
  AU  - Huisman,Abe 
  AU  - Fredholm,Merete 
  AU  - van As,Pieter 
  AU  - S?nchez,Armand 
  T1  - Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.
  PY  - 2016
  KW  - 
  UR  - http://dx.doi.org/
  N2  - Taste receptors (TASRs) are essential for the body?s recognition of chemical compounds.  In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour.  Moreover, their relevance in other organs is now becoming evident.  In the intestine, they regulate nutrient absorption and gut motility.  Upon ligand binding, TASRs activate the appetite-reward circuitry to signal the nervous system and keep body homeostasis.  With the aim to identify genetic variation in the swine TASRs and in the genes from the appetite and the reward pathways, we have sequenced the exons of 201 TASRs and appetite-reward genes from 304 pigs belonging to ten breeds and to two phenotypically extreme groups from a F2 resource with data on growth and fat deposition.  
  L3  - 
  JF  - BMC Genomics
  VL  - 
  IS  - 
  ER  -