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Citation for Study 1982

Citation title: "Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus".

This study was previously identified under the legacy study ID S1965 (Status: Published).

Citation

Sato J., Shinohara A., Miyashita N., Koshimoto C., Tsuchiya K., Nakahara I., Morita T., Yonekawa H., Moriwaki K., & Yamaguchi Y. 2007. Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus. Mammalian Genome, null.

Authors

• Sato J.
• Shinohara A.
• Miyashita N.
• Koshimoto C.
• Tsuchiya K.
• Nakahara I.
• Morita T.
• Yonekawa H.
• Moriwaki K.
• Yamaguchi Y.

Abstract

Genetic characterization of a wild-derived house mouse, Mus musculus, originally collected near Lake Balkhash in the Republic of Kazakhstan, was performed by examining protein polymorphisms and nucleotide sequences for the hemoglobin beta chain (HBB) subunits. Protein electrophoresis, which was performed on a cellulose-acetate plate, showed an independent mobility pattern representing a new, previously undiscovered haplotype. Neighbor-joining analyses of the HBB adult genes, i.e., HBB-T1 and HBB-T2, and the intergenic spacer region showed that the Lake Balkhash mouse possessed genomic components that were mixed from different haplotypes. Compared to the previously determined HBB haplotypes, d, p, and w1, the HBB-T1 gene and ca. 11 kb of the spacer region were most similar to the w1 haplotype; however, the remainder of the spacer region and the HBB-T2 gene were most similar to the d haplotype but may represent a still uncharacterized and divergent haplotype. The recombination event is predicted to have occurred 2.5 kb upstream of the HBB-T2 gene, and may have occurred through intersubspecific hybridization between mice of the musculus subspecies group (with the w1 haplotype) and the castaneus subspecies group (with the d-like haplotype). Alternatively, unknown subspecies group that is equidistantly divergent from each of these subspecies groups may have been involved. Our findings suggest reticulate evolution among the subspecies groups during the evolution of M. musculus.

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S1982
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref17372,
  	 author = {Jun J  Sato and Akio  Shinohara and Nobumoto  Miyashita and Chihiro  Koshimoto and Kimiyuki  Tsuchiya and Ikuyo  Nakahara and Tetsuo  Morita and Hiromichi  Yonekawa and Kazuo  Moriwaki and Yasunori  Yamaguchi},
  	 title = {Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus},
  	 year = {2007},
  	 keywords = {},
  	 doi = {},
  	 url = {},
  	 pmid = {},
  	 journal = {Mammalian Genome},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Genetic characterization of a wild-derived house mouse, Mus musculus, originally collected near Lake Balkhash in the Republic of Kazakhstan, was performed by examining protein polymorphisms and nucleotide sequences for the hemoglobin beta chain (HBB) subunits. Protein electrophoresis, which was performed on a cellulose-acetate plate, showed an independent mobility pattern representing a new, previously undiscovered haplotype. Neighbor-joining analyses of the HBB adult genes, i.e., HBB-T1 and HBB-T2, and the intergenic spacer region showed that the Lake Balkhash mouse possessed genomic components that were mixed from different haplotypes. Compared to the previously determined HBB haplotypes, d, p, and w1, the HBB-T1 gene and ca. 11 kb of the spacer region were most similar to the w1 haplotype; however, the remainder of the spacer region and the HBB-T2 gene were most similar to the d haplotype but may represent a still uncharacterized and divergent haplotype. The recombination event is predicted to have occurred 2.5 kb upstream of the HBB-T2 gene, and may have occurred through intersubspecific hybridization between mice of the musculus subspecies group (with the w1 haplotype) and the castaneus subspecies group (with the d-like haplotype). Alternatively, unknown subspecies group that is equidistantly divergent from each of these subspecies groups may have been involved. Our findings suggest reticulate evolution among the subspecies groups during the evolution of M. musculus.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 17372
  AU  - Sato,Jun J 
  AU  - Shinohara,Akio 
  AU  - Miyashita,Nobumoto 
  AU  - Koshimoto,Chihiro 
  AU  - Tsuchiya,Kimiyuki 
  AU  - Nakahara,Ikuyo 
  AU  - Morita,Tetsuo 
  AU  - Yonekawa,Hiromichi 
  AU  - Moriwaki,Kazuo 
  AU  - Yamaguchi,Yasunori 
  T1  - Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus
  PY  - 2007
  KW  - 
  UR  - 
  N2  - Genetic characterization of a wild-derived house mouse, Mus musculus, originally collected near Lake Balkhash in the Republic of Kazakhstan, was performed by examining protein polymorphisms and nucleotide sequences for the hemoglobin beta chain (HBB) subunits. Protein electrophoresis, which was performed on a cellulose-acetate plate, showed an independent mobility pattern representing a new, previously undiscovered haplotype. Neighbor-joining analyses of the HBB adult genes, i.e., HBB-T1 and HBB-T2, and the intergenic spacer region showed that the Lake Balkhash mouse possessed genomic components that were mixed from different haplotypes. Compared to the previously determined HBB haplotypes, d, p, and w1, the HBB-T1 gene and ca. 11 kb of the spacer region were most similar to the w1 haplotype; however, the remainder of the spacer region and the HBB-T2 gene were most similar to the d haplotype but may represent a still uncharacterized and divergent haplotype. The recombination event is predicted to have occurred 2.5 kb upstream of the HBB-T2 gene, and may have occurred through intersubspecific hybridization between mice of the musculus subspecies group (with the w1 haplotype) and the castaneus subspecies group (with the d-like haplotype). Alternatively, unknown subspecies group that is equidistantly divergent from each of these subspecies groups may have been involved. Our findings suggest reticulate evolution among the subspecies groups during the evolution of M. musculus.
  L3  - 
  JF  - Mammalian Genome
  VL  - 
  IS  - 
  ER  -