@ARTICLE{TreeBASE2Ref27821,
author = {Takuro Nunoura and Yoshihiro Takaki},
title = {A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile},
year = {2018},
keywords = {chemolithoautotrophic},
doi = {10.1126/science.aao3407},
url = {http://},
pmid = {},
journal = {Science},
volume = {359},
number = {6375},
pages = {559--563},
abstract = {Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic and metabolomic analyses of a deeply-branching chemolithotrophic Thermosulfidibacter takaii ABI70S6T revealed an unprecedented reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) but not with the ATP-dependent citrate cleavage reactions that had been regarded essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the (r)TCA cycle and raises the possibilities of a chemolithomixotrophic origin of life.}
}
Citation for Study 21831
Citation title:
"A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile".
Study name:
"A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile".
This study is part of submission 21831
(Status: Published).
Citation
Nunoura T., & Takaki Y. 2018. A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile. Science, 359(6375): 559-563.
Authors
-
Nunoura T.
-
Takaki Y.
(submitter)
+81-46-867-9648
Abstract
Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic and metabolomic analyses of a deeply-branching chemolithotrophic Thermosulfidibacter takaii ABI70S6T revealed an unprecedented reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) but not with the ATP-dependent citrate cleavage reactions that had been regarded essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the (r)TCA cycle and raises the possibilities of a chemolithomixotrophic origin of life.
Keywords
chemolithoautotrophic
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S21831
- Other versions:
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- Show BibTeX reference
@ARTICLE{TreeBASE2Ref27821,
author = {Takuro Nunoura and Yoshihiro Takaki},
title = {A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile},
year = {2018},
keywords = {chemolithoautotrophic},
doi = {10.1126/science.aao3407},
url = {http://},
pmid = {},
journal = {Science},
volume = {359},
number = {6375},
pages = {559--563},
abstract = {Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic and metabolomic analyses of a deeply-branching chemolithotrophic Thermosulfidibacter takaii ABI70S6T revealed an unprecedented reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) but not with the ATP-dependent citrate cleavage reactions that had been regarded essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the (r)TCA cycle and raises the possibilities of a chemolithomixotrophic origin of life.}
}
- Show RIS reference
TY - JOUR
ID - 27821
AU - Nunoura,Takuro
AU - Takaki,Yoshihiro
T1 - A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile
PY - 2018
KW - chemolithoautotrophic
UR - http://dx.doi.org/10.1126/science.aao3407
N2 - Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic and metabolomic analyses of a deeply-branching chemolithotrophic Thermosulfidibacter takaii ABI70S6T revealed an unprecedented reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) but not with the ATP-dependent citrate cleavage reactions that had been regarded essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the (r)TCA cycle and raises the possibilities of a chemolithomixotrophic origin of life.
L3 - 10.1126/science.aao3407
JF - Science
VL - 359
IS - 6375
SP - 559
EP - 563
ER -
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