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Citation for Study 22429

Citation title: "Evidence of positive selection suggests possible role of aquaporins in the water-to-land transition of mudskippers".

Study name: "Evidence of positive selection suggests possible role of aquaporins in the water-to-land transition of mudskippers".

This study is part of submission 22429 (Status: Published).

Citation

Lorente-martinez H., Agorreta A., Torres-sanchez M., & San mauro D. 2018. Evidence of positive selection suggests possible role of aquaporins in the water-to-land transition of mudskippers. Organisms Diversity & Evolution, https://doi.org/10.1007/s13127-018-0382-6.

Authors

• Lorente-martinez H.
• Agorreta A.
• Torres-sanchez M.
• San mauro D. (submitter)

Abstract

Aquaporins are integral membrane proteins that exchange water and small solutes. They played an important role in the colonisation of terrestrial environments by tetrapod ancestors via the appearance of three exclusive paralogs. Like early tetrapods, mudskippers represent an independent case of amphibious lifestyle evolution that is unparalleled by other extant fish groups. Given this lifestyle parallelism and that aquaporins were relevant for tetrapod terrestrialisation, this study examines the aquaporins in mudskippers to investigate whether similar changes in aquaporins could have possibly occurred during their water-to-land transition.We have catalogued aquaporin genes in four mudskipper genomes and studied their diversity and molecular evolution (including detection of positive selection) in a broad phylogenetic context of vertebrates. Our genomic screening returned 55 aquaporin genes for mudskippers (none of them constituting novel paralogs) that can be assigned to 10 different known classes. We detected signatures of positive selection in AQP10a and AQP11b in mudskippers (both the entire clade and the clade containing the most terrestrial species, implying different evolutionary times). This suggests possible alteration of the molecular function of such paralogs caused by changes at specific protein sequence positions, some of them located in relatively close proximity to parts of the molecule involved in pore formation and substrate selectivity. Given the importance of aquaporins for osmotic regulation in fishes, it might be possible that these selective changes (perhaps allowing permeability to new solutes) could have played a role during the adaptation of mudskippers to an amphibious lifestyle.

Keywords

amphibious lifestyle, aquaporin, molecular evolution, mudskipper, positive selection

External links

• DOI: 10.1007/s13127-018-0382-6

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22429
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref28245,
  	 author = {Hector  Lorente-Martinez and Ainhoa  Agorreta and Maria  Torres-Sanchez and Diego  San Mauro},
  	 title = {Evidence of positive selection suggests possible role of aquaporins in the water-to-land transition of mudskippers},
  	 year = {2018},
  	 keywords = {amphibious lifestyle, aquaporin, molecular evolution, mudskipper, positive selection},
  	 doi = {10.1007/s13127-018-0382-6},
  	 url = {},
  	 pmid = {},
  	 journal = {Organisms Diversity & Evolution},
  	 volume = {https://doi.org/10.1007/s13127-018-0382-6},
  	 number = {},
  	 pages = {},
  	 abstract = {Aquaporins are integral membrane proteins that exchange water and small solutes. They played an important role in the colonisation of terrestrial environments by tetrapod ancestors via the appearance of three exclusive paralogs. Like early tetrapods, mudskippers represent an independent case of amphibious lifestyle evolution that is unparalleled by other extant fish groups. Given this lifestyle parallelism and that aquaporins were relevant for tetrapod terrestrialisation, this study examines the aquaporins in mudskippers to investigate whether similar changes in aquaporins could have possibly occurred during their water-to-land transition.We have catalogued aquaporin genes in four mudskipper genomes and studied their diversity and molecular evolution (including detection of positive selection) in a broad phylogenetic context of vertebrates. Our genomic screening returned 55 aquaporin genes for mudskippers (none of them constituting novel paralogs) that can be assigned to 10 different known classes. We detected signatures of positive selection in AQP10a and AQP11b in mudskippers (both the entire clade and the clade containing the most terrestrial species, implying different evolutionary times). This suggests possible alteration of the molecular function of such paralogs caused by changes at specific protein sequence positions, some of them located in relatively close proximity to parts of the molecule involved in pore formation and substrate selectivity. Given the importance of aquaporins for osmotic regulation in fishes, it might be possible that these selective changes (perhaps allowing permeability to new solutes) could have played a role during the adaptation of mudskippers to an amphibious lifestyle.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 28245
  AU  - Lorente-Martinez,Hector 
  AU  - Agorreta,Ainhoa 
  AU  - Torres-Sanchez,Maria 
  AU  - San Mauro,Diego 
  T1  - Evidence of positive selection suggests possible role of aquaporins in the water-to-land transition of mudskippers
  PY  - 2018
  KW  - amphibious lifestyle
  KW  - aquaporin
  KW  - molecular evolution
  KW  - mudskipper
  KW  - positive selection
  UR  - 
  N2  - Aquaporins are integral membrane proteins that exchange water and small solutes. They played an important role in the colonisation of terrestrial environments by tetrapod ancestors via the appearance of three exclusive paralogs. Like early tetrapods, mudskippers represent an independent case of amphibious lifestyle evolution that is unparalleled by other extant fish groups. Given this lifestyle parallelism and that aquaporins were relevant for tetrapod terrestrialisation, this study examines the aquaporins in mudskippers to investigate whether similar changes in aquaporins could have possibly occurred during their water-to-land transition.We have catalogued aquaporin genes in four mudskipper genomes and studied their diversity and molecular evolution (including detection of positive selection) in a broad phylogenetic context of vertebrates. Our genomic screening returned 55 aquaporin genes for mudskippers (none of them constituting novel paralogs) that can be assigned to 10 different known classes. We detected signatures of positive selection in AQP10a and AQP11b in mudskippers (both the entire clade and the clade containing the most terrestrial species, implying different evolutionary times). This suggests possible alteration of the molecular function of such paralogs caused by changes at specific protein sequence positions, some of them located in relatively close proximity to parts of the molecule involved in pore formation and substrate selectivity. Given the importance of aquaporins for osmotic regulation in fishes, it might be possible that these selective changes (perhaps allowing permeability to new solutes) could have played a role during the adaptation of mudskippers to an amphibious lifestyle.
  L3  - 10.1007/s13127-018-0382-6
  JF  - Organisms Diversity & Evolution
  VL  - https://doi.org/10.1007/s13127-018-0382-6
  IS  - 
  ER  -