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Citation for Study 24803

Citation title: "RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their their implications for molecular systematics".

Study name: "RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their their implications for molecular systematics".

This study is part of submission 24803 (Status: Published).

Citation

Li Y. 2020. RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their their implications for molecular systematics. IMA Fungus, .

Authors

Li Y.

Abstract

Different hypotheses have been proposed to interpret the observed unusual ITS (internal transcribed spacer) sequences in Ophiocordyceps sinensis. The coexistence of diverged ITS paralogs in a single genome was previously shown by amplifying the ITS region from mono-ascospore isolates using specific primers designed for different ITS paralog groups. Among those paralogs, are AT-biased ITS sequences which were hypothesized to result from repeat-induced point mutation (RIP). This is a process that detects and mutates repetitive DNA and frequently leads to epigenetic silencing, and these mutations have been interpreted as pseudogenes. Here we investigate the occurrence and frequency of ITS pseudogenes in populations of O. sinensis using large-scale sampling, and discusses the implications of ITS pseudogenes for fungal phylogenetic and evolutionary studies. Our results demonstrate a wide distribution of ITS pseudogenes amongst different geographic populations, and indicate how ITS pseudogenes can contribute to the reconstruction of the evolutionary history of the species.

Keywords

caterpillar fungus, Cordyceps sinensis, ITS pseudogene, haplotype, phylogeny

External links

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S24803
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref30920,
	 author = {Yi  Li},
	 title = {RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their their implications for molecular systematics},
	 year = {2020},
	 keywords = {caterpillar fungus, Cordyceps sinensis, ITS pseudogene, haplotype, phylogeny},
	 doi = {},
	 url = {http://},
	 pmid = {},
	 journal = {IMA Fungus},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {Different hypotheses have been proposed to interpret the observed unusual ITS (internal transcribed spacer) sequences in Ophiocordyceps sinensis. The coexistence of diverged ITS paralogs in a single genome was previously shown by amplifying the ITS region from mono-ascospore isolates using specific primers designed for different ITS paralog groups. Among those paralogs, are AT-biased ITS sequences which were hypothesized to result from repeat-induced point mutation (RIP). This is a process that detects and mutates repetitive DNA and frequently leads to epigenetic silencing, and these mutations have been interpreted as pseudogenes. Here we investigate the occurrence and frequency of ITS pseudogenes in populations of O. sinensis using large-scale sampling, and discusses the implications of ITS pseudogenes for fungal phylogenetic and evolutionary studies. Our results demonstrate a wide distribution of ITS pseudogenes amongst different geographic populations, and indicate how ITS pseudogenes can contribute to the reconstruction of the evolutionary history of the species.}
}

Show RIS reference

		TY  - JOUR
ID  - 30920
AU  - Li,Yi 
T1  - RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their their implications for molecular systematics
PY  - 2020
KW  - caterpillar fungus
KW  - Cordyceps sinensis
KW  - ITS pseudogene
KW  - haplotype
KW  - phylogeny
UR  - http://dx.doi.org/
N2  - Different hypotheses have been proposed to interpret the observed unusual ITS (internal transcribed spacer) sequences in Ophiocordyceps sinensis. The coexistence of diverged ITS paralogs in a single genome was previously shown by amplifying the ITS region from mono-ascospore isolates using specific primers designed for different ITS paralog groups. Among those paralogs, are AT-biased ITS sequences which were hypothesized to result from repeat-induced point mutation (RIP). This is a process that detects and mutates repetitive DNA and frequently leads to epigenetic silencing, and these mutations have been interpreted as pseudogenes. Here we investigate the occurrence and frequency of ITS pseudogenes in populations of O. sinensis using large-scale sampling, and discusses the implications of ITS pseudogenes for fungal phylogenetic and evolutionary studies. Our results demonstrate a wide distribution of ITS pseudogenes amongst different geographic populations, and indicate how ITS pseudogenes can contribute to the reconstruction of the evolutionary history of the species.
L3  - 
JF  - IMA Fungus
VL  - 
IS  - 
ER  -