@ARTICLE{TreeBASE2Ref30566,
author = {Vianney Tricou and Julie Bouscaillou and Gina Laure Laghoe-Nguembe and Aubin B?r? and Xavier Konamna and Benjamin S?l?kon and Emmanuel Nakoun? and Mirdad Kazanji and Narcisse Patrice Komas},
title = {Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009},
year = {2020},
keywords = {Hepatitis E Virus, Waterborne Disease, Preventable Disease, Epidemiology, Central Africa},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Infectious Diseases},
volume = {},
number = {},
pages = {},
abstract = {Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity
and mortality in countries with poor access to clean water and sanitation. Our study
aimed to investigate the situation of HEV infections in the Central African Republic
(CAR).
Methods: A retrospective analysis of the blood samples and notification forms collected
through the national yellow fever (YF) surveillance program, but for which a diagnosis
of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific
RT-PCR.
Results: Of 2,883 YF-negative samples collected between between January 2008 and
December 2012, 745 (~26%) tested positive by at least either of the 2 tests used to
confirm HEV cases. The results revealed that the CAR was hit by a large outbreak in
2008 and 2009. The results also showed a clear seasonal pattern with correlation
between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that
the circulating strains belonged to genotypes 1e and 2b.
Conclusions: Overall, this study provides further evidences that HEV can be a
significant cause of acute febrile jaundice, particularly among adults during rainy
season or flood, in a country from Sub-Saharan Africa.}
}
Citation for Study 25902
Citation title:
"Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009".
Study name:
"Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009".
This study is part of submission 25902
(Status: Published).
Citation
Tricou V., Bouscaillou J., Laghoe-nguembe G., B?r? A., Konamna X., S?l?kon B., Nakoun? E., Kazanji M., & Komas N.P. 2020. Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009. BMC Infectious Diseases, .
Authors
-
Tricou V.
(submitter)
+41791976056
-
Bouscaillou J.
-
Laghoe-nguembe G.
-
B?r? A.
-
Konamna X.
-
S?l?kon B.
-
Nakoun? E.
-
Kazanji M.
-
Komas N.P.
Abstract
Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity
and mortality in countries with poor access to clean water and sanitation. Our study
aimed to investigate the situation of HEV infections in the Central African Republic
(CAR).
Methods: A retrospective analysis of the blood samples and notification forms collected
through the national yellow fever (YF) surveillance program, but for which a diagnosis
of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific
RT-PCR.
Results: Of 2,883 YF-negative samples collected between between January 2008 and
December 2012, 745 (~26%) tested positive by at least either of the 2 tests used to
confirm HEV cases. The results revealed that the CAR was hit by a large outbreak in
2008 and 2009. The results also showed a clear seasonal pattern with correlation
between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that
the circulating strains belonged to genotypes 1e and 2b.
Conclusions: Overall, this study provides further evidences that HEV can be a
significant cause of acute febrile jaundice, particularly among adults during rainy
season or flood, in a country from Sub-Saharan Africa.
Keywords
Hepatitis E Virus, Waterborne Disease, Preventable Disease, Epidemiology, Central Africa
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S25902
- Other versions:
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NeXML
- Show BibTeX reference
@ARTICLE{TreeBASE2Ref30566,
author = {Vianney Tricou and Julie Bouscaillou and Gina Laure Laghoe-Nguembe and Aubin B?r? and Xavier Konamna and Benjamin S?l?kon and Emmanuel Nakoun? and Mirdad Kazanji and Narcisse Patrice Komas},
title = {Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009},
year = {2020},
keywords = {Hepatitis E Virus, Waterborne Disease, Preventable Disease, Epidemiology, Central Africa},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Infectious Diseases},
volume = {},
number = {},
pages = {},
abstract = {Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity
and mortality in countries with poor access to clean water and sanitation. Our study
aimed to investigate the situation of HEV infections in the Central African Republic
(CAR).
Methods: A retrospective analysis of the blood samples and notification forms collected
through the national yellow fever (YF) surveillance program, but for which a diagnosis
of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific
RT-PCR.
Results: Of 2,883 YF-negative samples collected between between January 2008 and
December 2012, 745 (~26%) tested positive by at least either of the 2 tests used to
confirm HEV cases. The results revealed that the CAR was hit by a large outbreak in
2008 and 2009. The results also showed a clear seasonal pattern with correlation
between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that
the circulating strains belonged to genotypes 1e and 2b.
Conclusions: Overall, this study provides further evidences that HEV can be a
significant cause of acute febrile jaundice, particularly among adults during rainy
season or flood, in a country from Sub-Saharan Africa.}
}
- Show RIS reference
TY - JOUR
ID - 30566
AU - Tricou,Vianney
AU - Bouscaillou,Julie
AU - Laghoe-Nguembe,Gina Laure
AU - B?r?,Aubin
AU - Konamna,Xavier
AU - S?l?kon,Benjamin
AU - Nakoun?,Emmanuel
AU - Kazanji,Mirdad
AU - Komas,Narcisse Patrice
T1 - Outbreak of Hepatitis E Virus Infections Associated with Rainfalls in the Central African Republic in 2008-2009
PY - 2020
KW - Hepatitis E Virus
KW - Waterborne Disease
KW - Preventable Disease
KW - Epidemiology
KW - Central Africa
UR - http://dx.doi.org/
N2 - Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity
and mortality in countries with poor access to clean water and sanitation. Our study
aimed to investigate the situation of HEV infections in the Central African Republic
(CAR).
Methods: A retrospective analysis of the blood samples and notification forms collected
through the national yellow fever (YF) surveillance program, but for which a diagnosis
of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific
RT-PCR.
Results: Of 2,883 YF-negative samples collected between between January 2008 and
December 2012, 745 (~26%) tested positive by at least either of the 2 tests used to
confirm HEV cases. The results revealed that the CAR was hit by a large outbreak in
2008 and 2009. The results also showed a clear seasonal pattern with correlation
between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that
the circulating strains belonged to genotypes 1e and 2b.
Conclusions: Overall, this study provides further evidences that HEV can be a
significant cause of acute febrile jaundice, particularly among adults during rainy
season or flood, in a country from Sub-Saharan Africa.
L3 -
JF - BMC Infectious Diseases
VL -
IS -
ER -
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