@ARTICLE{TreeBASE2Ref15698,
author = {Kenneth M. Halanych and Terence J. Robinson},
title = {The utility of cytochrome b and 12S rDNA data for phylogeny reconstruction of leporid (Lagomorpha) genera.},
year = {1999},
keywords = {Leporidae; Rabbits; Cytochrome b; 12S rRNA; Lagomorph evolution; Saturation; Phylogenetics},
doi = {10.1007/PL00006481},
url = {},
pmid = {},
journal = {Journal of Molecular Evolution},
volume = {48},
number = {},
pages = {369--379},
abstract = {Partial sequences of two mitochondrial genes, the 12S ribosomal gene (739 bp) and the cytochrome b gene (672 bp), were analyzed in hopes of reconstructing the evolutionary relationships of 11 leporid species, representative of seven genera. However, partial cytochrome b sequences were of little phylogenetic value in this study. A suite of pairwise comparisons between taxa revealed that at the intergeneric level, the cytochrome b gene is saturated at synonymous coding positions due to multiple substitution events. Furthermore, variation at the nonsynonymous positions is limited, rendering the cytochrome b gene of little phylogenetic value for assessing the relationships between leporid genera. If the cytochrome b data were analyzed without accounting for these two classes of nucleotides (i.e., synonymous and nonsynonymous sites), one may incorrectly conclude that signal exists in the cytochrome b data. The mitochondrial 12S rRNA gene, on the other hand, has not experienced excessive saturation at either stem or loop positions. Phylogenies reconstructed from the 12S rDNA data support hypotheses based on fossil evidence that the African rock rabbits (Pronolagus) are outside of the main leporid stock and that leporids experienced a rapid radiation. However, the molecular data suggest this radiation event occurred in the mid-Miocene several millions of years earlier that the Pleistocene dates suggested by paleontological evidence.}
}
Citation for Study 422
Citation title:
"The utility of cytochrome b and 12S rDNA data for phylogeny reconstruction of leporid (Lagomorpha) genera.".
This study was previously identified under the legacy study ID S373
(Status: Published).
Citation
Halanych K., & Robinson T. 1999. The utility of cytochrome b and 12S rDNA data for phylogeny reconstruction of leporid (Lagomorpha) genera. Journal of Molecular Evolution, 48: 369-379.
Authors
Abstract
Partial sequences of two mitochondrial genes, the 12S ribosomal gene (739 bp) and the cytochrome b gene (672 bp), were analyzed in hopes of reconstructing the evolutionary relationships of 11 leporid species, representative of seven genera. However, partial cytochrome b sequences were of little phylogenetic value in this study. A suite of pairwise comparisons between taxa revealed that at the intergeneric level, the cytochrome b gene is saturated at synonymous coding positions due to multiple substitution events. Furthermore, variation at the nonsynonymous positions is limited, rendering the cytochrome b gene of little phylogenetic value for assessing the relationships between leporid genera. If the cytochrome b data were analyzed without accounting for these two classes of nucleotides (i.e., synonymous and nonsynonymous sites), one may incorrectly conclude that signal exists in the cytochrome b data. The mitochondrial 12S rRNA gene, on the other hand, has not experienced excessive saturation at either stem or loop positions. Phylogenies reconstructed from the 12S rDNA data support hypotheses based on fossil evidence that the African rock rabbits (Pronolagus) are outside of the main leporid stock and that leporids experienced a rapid radiation. However, the molecular data suggest this radiation event occurred in the mid-Miocene several millions of years earlier that the Pleistocene dates suggested by paleontological evidence.
Keywords
Leporidae; Rabbits; Cytochrome b; 12S rRNA; Lagomorph evolution; Saturation; Phylogenetics
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S422
- Other versions:
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- Show BibTeX reference
@ARTICLE{TreeBASE2Ref15698,
author = {Kenneth M. Halanych and Terence J. Robinson},
title = {The utility of cytochrome b and 12S rDNA data for phylogeny reconstruction of leporid (Lagomorpha) genera.},
year = {1999},
keywords = {Leporidae; Rabbits; Cytochrome b; 12S rRNA; Lagomorph evolution; Saturation; Phylogenetics},
doi = {10.1007/PL00006481},
url = {},
pmid = {},
journal = {Journal of Molecular Evolution},
volume = {48},
number = {},
pages = {369--379},
abstract = {Partial sequences of two mitochondrial genes, the 12S ribosomal gene (739 bp) and the cytochrome b gene (672 bp), were analyzed in hopes of reconstructing the evolutionary relationships of 11 leporid species, representative of seven genera. However, partial cytochrome b sequences were of little phylogenetic value in this study. A suite of pairwise comparisons between taxa revealed that at the intergeneric level, the cytochrome b gene is saturated at synonymous coding positions due to multiple substitution events. Furthermore, variation at the nonsynonymous positions is limited, rendering the cytochrome b gene of little phylogenetic value for assessing the relationships between leporid genera. If the cytochrome b data were analyzed without accounting for these two classes of nucleotides (i.e., synonymous and nonsynonymous sites), one may incorrectly conclude that signal exists in the cytochrome b data. The mitochondrial 12S rRNA gene, on the other hand, has not experienced excessive saturation at either stem or loop positions. Phylogenies reconstructed from the 12S rDNA data support hypotheses based on fossil evidence that the African rock rabbits (Pronolagus) are outside of the main leporid stock and that leporids experienced a rapid radiation. However, the molecular data suggest this radiation event occurred in the mid-Miocene several millions of years earlier that the Pleistocene dates suggested by paleontological evidence.}
}
- Show RIS reference
TY - JOUR
ID - 15698
AU - Halanych,Kenneth M.
AU - Robinson,Terence J.
T1 - The utility of cytochrome b and 12S rDNA data for phylogeny reconstruction of leporid (Lagomorpha) genera.
PY - 1999
KW - Leporidae; Rabbits; Cytochrome b; 12S rRNA; Lagomorph evolution; Saturation; Phylogenetics
UR - http://dx.doi.org/10.1007/PL00006481
N2 - Partial sequences of two mitochondrial genes, the 12S ribosomal gene (739 bp) and the cytochrome b gene (672 bp), were analyzed in hopes of reconstructing the evolutionary relationships of 11 leporid species, representative of seven genera. However, partial cytochrome b sequences were of little phylogenetic value in this study. A suite of pairwise comparisons between taxa revealed that at the intergeneric level, the cytochrome b gene is saturated at synonymous coding positions due to multiple substitution events. Furthermore, variation at the nonsynonymous positions is limited, rendering the cytochrome b gene of little phylogenetic value for assessing the relationships between leporid genera. If the cytochrome b data were analyzed without accounting for these two classes of nucleotides (i.e., synonymous and nonsynonymous sites), one may incorrectly conclude that signal exists in the cytochrome b data. The mitochondrial 12S rRNA gene, on the other hand, has not experienced excessive saturation at either stem or loop positions. Phylogenies reconstructed from the 12S rDNA data support hypotheses based on fossil evidence that the African rock rabbits (Pronolagus) are outside of the main leporid stock and that leporids experienced a rapid radiation. However, the molecular data suggest this radiation event occurred in the mid-Miocene several millions of years earlier that the Pleistocene dates suggested by paleontological evidence.
L3 - 10.1007/PL00006481
JF - Journal of Molecular Evolution
VL - 48
IS -
SP - 369
EP - 379
ER -
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