@ARTICLE{TreeBASE2Ref20471, author = {Alex G Bick and Sarah E Calvo and Vamsi K Mootha}, title = {Evolutionary Diversity of the Mitochondrial Calcium Uniporter}, year = {2012}, keywords = {MCU MICU1 Calcium}, doi = {}, url = {http://}, pmid = {22605770}, journal = {Science}, volume = {336}, number = {6083}, pages = {886}, abstract = {Calcium uptake into mitochondria occurs via a recently identified uniporter, which represents a new class of ion channels. Here we characterize the phylogenomic distribution of its membrane spanning pore (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.} }

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