@ARTICLE{TreeBASE2Ref27882, author = {MAŁGORZATA WOJTKOWSKA and Dorota Buczek and Yutaka Suzuki and Victoria Shabardina and Wojciech Makałowski and Hanna Kmita}, title = {The emerging picture of the mitochondrial protein import complexes of Amoebozoa supergroup}, year = {2017}, keywords = {Amoebozoa, mitochondria, mitosomes, protein import, TIM22 complex, TIM23 complex, small Tims, MIA complex, PAM complex, OXA complex }, doi = {10.1186/s12864-017-4383-1}, url = {http://}, pmid = {}, journal = {BMC Genomics}, volume = {}, number = {}, pages = {}, abstract = {Background: The existence of mitochondria-related organelles (MROs) is proposed for eukaryotic organisms. The Amoebozoa includes some organisms that are known to have mitosomes but also organisms that have aerobic mitochondria. However, the mitochondrial protein apparatus of this supergroup remains largely unsampled, except for the mitochondrial outer membrane import complexes studied recently. Therefore, in this study we investigated the mitochondrial inner membrane and intermembrane space complexes, using the available genome and transcriptome sequences. Results: When compared with the canonical cognate complexes described for the yeast Saccharomyces cerevisiae, amoebozoans with aerobic mitochondria, display lower differences in the number of subunits predicted for these complexes than the mitochondrial outer membrane complexes, although the predicted subunits appear to display different levels of diversity in regard to phylogenetic position and isoform numbers. For the putative mitosome-bearing amoebozoans, the number of predicted subunits suggests the complex elimination distinctly more pronounced than in the case of the outer membrane ones. Conclusion: The results concern the problem of mitochondrial and mitosome protein import machinery structural variability and the reduction of their complexity within the currently defined supergroup of Amoebozoa. This results are crucial for better understanding of the Amoebozoa taxa of both biomedical and evolutionary importance. } }

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