@ARTICLE{TreeBASE2Ref21726,
author = {Ake Vastermark and Mathias Rask-Andersen and Rahul S Sawant and Jill L Reiter and Helgi B Schioth and Michael Williams},
title = {Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA},
year = {2013},
keywords = {INSRR, INSR, Receptor L domain, ectodomain, T. castaneum, Drosophila},
doi = {},
url = {http://},
pmid = {},
journal = {Journal of Systematics and Evolution},
volume = {},
number = {},
pages = {},
abstract = {Motivation: Truncated receptor ectodomains have been described for several classes of cell surface receptors, including those that bind to growth factors, cytokines, immunoglobulins, and adhesion molecules. Soluble receptor isoforms are typically generated by proteolytic cleavage of the cell surface receptor or by alternative splicing of RNA transcripts arising from the same gene encoding the full-length receptor. Both the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) families produce soluble receptor splice variants in vertebrates and truncated forms of insulin receptor-like sequences have been described previously in Drosophila. The EGFR and INSR ectodomains share significant sequence homology suggestive of a common evolutionary origin.
Results: We performed a phylogenetic analysis of the conserved receptor extracellular L1 and L2 subdomains in invertebrate species. We discovered novel truncated insulin receptor-like variants in several arthropod species. While the segregation of insulin receptor-like L1 and L2 domains indicated that an internal domain duplication had occurred only once, the generation of truncated insulin receptor-like sequences apparently has occurred multiple times.
}
}
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Citation title: "Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA".
