TreeBASE Search-Matrices for study 12826

@ARTICLE{TreeBASE2Ref20796, author = {Yael H. Edrey and Diana Casper and Dorothee Huchon and James Mele and Jonathan A. Gelfond and Deborah M. Kristan and Eviatar Nevo and Rochelle Buffenstein}, title = {Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.}, year = {2012}, keywords = {aging; cerebellum; erbb4; imum lifespan; max-; naked mole-rat; neuregulin-1; neurotrophic factors; spalax}, doi = {10.1111/j.1474-9726.2011.00772.x}, url = {http://dx.doi.org/10.5061/dryad.3h3f3380}, pmid = {22103690}, journal = {Aging Cell}, volume = {11}, number = {2}, pages = {213--222}, abstract = {Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. glaber at different ages ranging from 1 day to 26 years and found that levels of NRG-1 and ErbB4 were sustained throughout development and adulthood. In addition, we compared seven rodent species with widely divergent (4-32 year) maximum lifespan potential (MLSP) and found that at a physiologically equivalent age, the longer-lived rodents had higher levels of NRG-1 and ErbB4. Moreover, phylogenetic independent contrast analyses revealed that this significant strong correlation between MLSP and NRG-1 levels was independent of phylogeny. These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity.} }