CiteULike

Delicious

Connotea

Citation for Study 12826

Citation title: "Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.".

Study name: "Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.".

This study is part of submission 12826 (Status: Published).

Citation

Edrey Y.H., Casper D., Huchon D., Mele J., Gelfond J.A., Kristan D.M., Nevo E., & Buffenstein R. 2012. Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Aging Cell, 11(2): 213-222.

Authors

• Edrey Y.H.
• Casper D.
• Huchon D.
• Mele J.
• Gelfond J.A.
• Kristan D.M.
• Nevo E.
• Buffenstein R.

Abstract

Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. glaber at different ages ranging from 1 day to 26 years and found that levels of NRG-1 and ErbB4 were sustained throughout development and adulthood. In addition, we compared seven rodent species with widely divergent (4-32 year) maximum lifespan potential (MLSP) and found that at a physiologically equivalent age, the longer-lived rodents had higher levels of NRG-1 and ErbB4. Moreover, phylogenetic independent contrast analyses revealed that this significant strong correlation between MLSP and NRG-1 levels was independent of phylogeny. These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity.

Keywords

aging; cerebellum; erbb4; imum lifespan; max-; naked mole-rat; neuregulin-1; neurotrophic factors; spalax

External links

• DOI: 10.1111/j.1474-9726.2011.00772.x
• PMID: 22103690
• Other URL: http://dx.doi.org/10.5061/dryad.3h3f3380

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S12826
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref20796,
  	 author = {Yael H. Edrey and Diana  Casper and Dorothee  Huchon and James  Mele and Jonathan A. Gelfond and Deborah M. Kristan and Eviatar  Nevo and Rochelle  Buffenstein},
  	 title = {Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.},
  	 year = {2012},
  	 keywords = {aging; cerebellum; erbb4; imum lifespan; max-; naked mole-rat; neuregulin-1; neurotrophic factors; spalax},
  	 doi = {10.1111/j.1474-9726.2011.00772.x},
  	 url = {http://dx.doi.org/10.5061/dryad.3h3f3380},
  	 pmid = {22103690},
  	 journal = {Aging Cell},
  	 volume = {11},
  	 number = {2},
  	 pages = {213--222},
  	 abstract = {Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. glaber at different ages ranging from 1 day to 26 years and found that levels of NRG-1 and ErbB4 were sustained throughout development and adulthood. In addition, we compared seven rodent species with widely divergent (4-32 year) maximum lifespan potential (MLSP) and found that at a physiologically equivalent age, the longer-lived rodents had higher levels of NRG-1 and ErbB4. Moreover, phylogenetic independent contrast analyses revealed that this significant strong correlation between MLSP and NRG-1 levels was independent of phylogeny. These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 20796
  AU  - Edrey,Yael H.
  AU  - Casper,Diana 
  AU  - Huchon,Dorothee 
  AU  - Mele,James 
  AU  - Gelfond,Jonathan A.
  AU  - Kristan,Deborah M.
  AU  - Nevo,Eviatar 
  AU  - Buffenstein,Rochelle 
  T1  - Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.
  PY  - 2012
  KW  - aging; cerebellum; erbb4; imum lifespan; max-; naked mole-rat; neuregulin-1; neurotrophic factors; spalax
  UR  - http://dx.doi.org/10.5061/dryad.3h3f3380
  N2  - Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. glaber at different ages ranging from 1 day to 26 years and found that levels of NRG-1 and ErbB4 were sustained throughout development and adulthood. In addition, we compared seven rodent species with widely divergent (4-32 year) maximum lifespan potential (MLSP) and found that at a physiologically equivalent age, the longer-lived rodents had higher levels of NRG-1 and ErbB4. Moreover, phylogenetic independent contrast analyses revealed that this significant strong correlation between MLSP and NRG-1 levels was independent of phylogeny. These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity.
  L3  - 10.1111/j.1474-9726.2011.00772.x
  JF  - Aging Cell
  VL  - 11
  IS  - 2
  SP  - 213
  EP  - 222
  ER  -