@ARTICLE{TreeBASE2Ref21552, author = {Guojie Zhang and Christopher Cowled and Zhengli Shi and Zhiyong Huang and Kimberly A Bishop-Lilly and Xiaodong Fang and James W Wynne and Zhiqiang Xiong and Michelle L Baker and Wei Zhao and Mary Tachedjian and Yabing Zhu and Peng Zhou and Xuanting Jiang and Justin Ng and Lan Yang and Lijun Wu and Jin Xiao and Yue Feng and Xiaoqing Sun and Yuanxin Chen and Yong Zhang and Glenn A Marsh and Gary Crameri and Christopher C Broder and Kenneth G Frey and Lin-Fa Wang and Jun Wang}, title = {Comparative analysis of bat genomes provides insight into the evolution of flight and immunity}, year = {2012}, keywords = {Comparative analysis of bat genomes provides insight into the evolution of flight and immunity}, doi = {10.1126/science.1230835}, url = {http://www.sciencemag.org/content/early/2012/12/19/science.1230835.abstract}, pmid = {23258410}, journal = {Science}, volume = {}, number = {}, pages = {}, abstract = {Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world?s most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor??B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution. } }

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