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Citation for Study 13654

Citation title: "Comparative analysis of bat genomes provides insight into the evolution of flight and immunity".

Study name: "Comparative analysis of bat genomes provides insight into the evolution of flight and immunity".

This study is part of submission 13654 (Status: Published).

Citation

Zhang G., Cowled C., Shi Z., Huang Z., Bishop-lilly K.A., Fang X., Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Sun X., Chen Y., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L., & Wang J. 2012. Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. Science, .

Authors

• Zhang G.
• Cowled C.
• Shi Z.
• Huang Z. (submitter)
• Bishop-lilly K.A.
• Fang X.
• Wynne J.W.
• Xiong Z.
• Baker M.L.
• Zhao W.
• Tachedjian M.
• Zhu Y.
• Zhou P.
• Jiang X.
• Ng J.
• Yang L.
• Wu L.
• Xiao J.
• Feng Y.
• Sun X.
• Chen Y.
• Zhang Y.
• Marsh G.A.
• Crameri G.
• Broder C.C.
• Frey K.G.
• Wang L.
• Wang J.

Abstract

Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world?s most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor??B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

Keywords

Comparative analysis of bat genomes provides insight into the evolution of flight and immunity

External links

• DOI: 10.1126/science.1230835
• PMID: 23258410
• Other URL: http://www.sciencemag.org/content/early/2012/12/19/science.1230835.abstract

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S13654
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref21552,
  	 author = {Guojie  Zhang and Christopher  Cowled and Zhengli  Shi and Zhiyong  Huang and Kimberly A Bishop-Lilly and Xiaodong  Fang and James W Wynne and Zhiqiang  Xiong and Michelle L Baker and Wei  Zhao and Mary  Tachedjian and Yabing  Zhu and Peng  Zhou and Xuanting  Jiang and Justin  Ng and Lan  Yang and Lijun  Wu and Jin  Xiao and Yue  Feng and Xiaoqing  Sun and Yuanxin  Chen and Yong  Zhang and Glenn A Marsh and Gary  Crameri and Christopher C Broder and Kenneth G Frey and Lin-Fa  Wang and Jun  Wang},
  	 title = {Comparative analysis of bat genomes provides insight into the evolution of flight and immunity},
  	 year = {2012},
  	 keywords = {Comparative analysis of bat genomes provides insight into the evolution of flight and immunity},
  	 doi = {10.1126/science.1230835},
  	 url = {http://www.sciencemag.org/content/early/2012/12/19/science.1230835.abstract},
  	 pmid = {23258410},
  	 journal = {Science},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world?s most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor??B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution. }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 21552
  AU  - Zhang,Guojie 
  AU  - Cowled,Christopher 
  AU  - Shi,Zhengli 
  AU  - Huang,Zhiyong 
  AU  - Bishop-Lilly,Kimberly A
  AU  - Fang,Xiaodong 
  AU  - Wynne,James W
  AU  - Xiong,Zhiqiang 
  AU  - Baker,Michelle L
  AU  - Zhao,Wei 
  AU  - Tachedjian,Mary 
  AU  - Zhu,Yabing 
  AU  - Zhou,Peng 
  AU  - Jiang,Xuanting 
  AU  - Ng,Justin 
  AU  - Yang,Lan 
  AU  - Wu,Lijun 
  AU  - Xiao,Jin 
  AU  - Feng,Yue 
  AU  - Sun,Xiaoqing 
  AU  - Chen,Yuanxin 
  AU  - Zhang,Yong 
  AU  - Marsh,Glenn A
  AU  - Crameri,Gary 
  AU  - Broder,Christopher C
  AU  - Frey,Kenneth G
  AU  - Wang,Lin-Fa 
  AU  - Wang,Jun 
  T1  - Comparative analysis of bat genomes provides insight into the evolution of flight and immunity
  PY  - 2012
  KW  - Comparative analysis of bat genomes provides insight into the evolution of flight and immunity
  UR  - http://www.sciencemag.org/content/early/2012/12/19/science.1230835.abstract
  N2  - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world?s most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor??B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution. 
  L3  - 10.1126/science.1230835
  JF  - Science
  VL  - 
  IS  - 
  ER  -