@ARTICLE{TreeBASE2Ref25542,
author = {Martin Plasil and Elmira Mohandesan and Robert Fitak and Petra Musilova and Svatava Kubickova and Pamela Burger and Petr Horin},
title = {The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes},
year = {2016},
keywords = {MHC, exon 2, wild two-humped camel, Bactrian camel, dromedary, Camelini, aDNA},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Genomics},
volume = {},
number = {},
pages = {},
abstract = {This study brings first information on the major histocompatibility complex (MHC) of three species of Old World camelids, Camelus bactrianus, Camelus ferus and Camelus dromedarius. Physical mapping located the MHC region to the chromosome 20 in Camelus dromedarius. Cytogenetic and comparative analyses of whole genome sequences showed that the order of the three major sub-regions on this chromosome is ?Centromere - Class II ? Class III ? Class I?. The overall genomic organization is highly similar to the cattle MHC region.
DRA, DRB, DQA and DQB exon 2 sequences encoding the antigen binding site of the corresponding class II antigen presenting molecules showed high degree of sequence similarity and extensive allele sharing across the three species. Unexpectedly low extent of polymorphism with low numbers of alleles and haplotypes was observed in all species, despite different geographic origins of the camels analyzed. Interestingly, the DRA locus was found to be polymorphic, with three alleles shared by all three species. DRA and DQA sequences retrieved from ancient DNA samples of Camelus dromedarius suggested that additional polymorphism might exist.
}
}
Matrices for Study 18850
Citation title:
"The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes".
Study name:
"The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes".
This study is part of submission 18850
(Status: Published).
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