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Citation for Study 18850

Citation title: "The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes".

Study name: "The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes".

This study is part of submission 18850 (Status: Published).

Citation

Plasil M., Mohandesan E., Fitak R., Musilova P., Kubickova S., Burger P., & Horin P. 2016. The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes. BMC Genomics, .

Authors

Plasil M. (submitter) +420541562289
Mohandesan E.
Fitak R.
Musilova P.
Kubickova S.
Burger P.
Horin P.

Abstract

This study brings first information on the major histocompatibility complex (MHC) of three species of Old World camelids, Camelus bactrianus, Camelus ferus and Camelus dromedarius. Physical mapping located the MHC region to the chromosome 20 in Camelus dromedarius. Cytogenetic and comparative analyses of whole genome sequences showed that the order of the three major sub-regions on this chromosome is ?Centromere - Class II ? Class III ? Class I?. The overall genomic organization is highly similar to the cattle MHC region. DRA, DRB, DQA and DQB exon 2 sequences encoding the antigen binding site of the corresponding class II antigen presenting molecules showed high degree of sequence similarity and extensive allele sharing across the three species. Unexpectedly low extent of polymorphism with low numbers of alleles and haplotypes was observed in all species, despite different geographic origins of the camels analyzed. Interestingly, the DRA locus was found to be polymorphic, with three alleles shared by all three species. DRA and DQA sequences retrieved from ancient DNA samples of Camelus dromedarius suggested that additional polymorphism might exist.

Keywords

MHC, exon 2, wild two-humped camel, Bactrian camel, dromedary, Camelini, aDNA

External links

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S18850
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref25542,
	 author = {Martin  Plasil and Elmira  Mohandesan and Robert  Fitak and Petra  Musilova and Svatava  Kubickova and Pamela  Burger and Petr  Horin},
	 title = {The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes},
	 year = {2016},
	 keywords = {MHC, exon 2, wild two-humped camel, Bactrian camel, dromedary, Camelini, aDNA},
	 doi = {},
	 url = {http://},
	 pmid = {},
	 journal = {BMC Genomics},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {This study brings first information on the major histocompatibility complex (MHC) of three species of Old World camelids, Camelus bactrianus, Camelus ferus and Camelus dromedarius. Physical mapping located the MHC region to the chromosome 20 in Camelus dromedarius. Cytogenetic and comparative analyses of whole genome sequences showed that the order of the three major sub-regions on this chromosome is ?Centromere - Class II ? Class III ? Class I?. The overall genomic organization is highly similar to the cattle MHC region.
	DRA, DRB, DQA and DQB exon 2 sequences encoding the antigen binding site of the corresponding class II antigen presenting molecules showed high degree of sequence similarity and extensive allele sharing across the three species. Unexpectedly low extent of polymorphism with low numbers of alleles and haplotypes was observed in all species, despite different geographic origins of the camels analyzed. Interestingly, the DRA locus was found to be polymorphic, with three alleles shared by all three species. DRA and DQA sequences retrieved from ancient DNA samples of Camelus dromedarius suggested that additional polymorphism might exist.
}
}

Show RIS reference

		TY  - JOUR
ID  - 25542
AU  - Plasil,Martin 
AU  - Mohandesan,Elmira 
AU  - Fitak,Robert 
AU  - Musilova,Petra 
AU  - Kubickova,Svatava 
AU  - Burger,Pamela 
AU  - Horin,Petr 
T1  - The Major Histocompatibility Complex in Old World camelids and low polymorphism of its class II genes
PY  - 2016
KW  - MHC
KW  - exon 2
KW  - wild two-humped camel
KW  - Bactrian camel
KW  - dromedary
KW  - Camelini
KW  - aDNA
UR  - http://dx.doi.org/
N2  - This study brings first information on the major histocompatibility complex (MHC) of three species of Old World camelids, Camelus bactrianus, Camelus ferus and Camelus dromedarius. Physical mapping located the MHC region to the chromosome 20 in Camelus dromedarius. Cytogenetic and comparative analyses of whole genome sequences showed that the order of the three major sub-regions on this chromosome is ?Centromere - Class II ? Class III ? Class I?. The overall genomic organization is highly similar to the cattle MHC region.
	DRA, DRB, DQA and DQB exon 2 sequences encoding the antigen binding site of the corresponding class II antigen presenting molecules showed high degree of sequence similarity and extensive allele sharing across the three species. Unexpectedly low extent of polymorphism with low numbers of alleles and haplotypes was observed in all species, despite different geographic origins of the camels analyzed. Interestingly, the DRA locus was found to be polymorphic, with three alleles shared by all three species. DRA and DQA sequences retrieved from ancient DNA samples of Camelus dromedarius suggested that additional polymorphism might exist.

L3  - 
JF  - BMC Genomics
VL  - 
IS  - 
ER  -