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Citation for Study 13435

Citation title: "Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase".

Study name: "Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase".

This study is part of submission 13435 (Status: Published).

Citation

Kohl K.P., Jones C.D., & Sekelsky J. 2012. Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase. Science, .

Authors

• Kohl K.P.
• Jones C.D.
• Sekelsky J. (submitter) 919-843-9400

Abstract

Generation of meiotic crossovers in many eukaryotes requires the elimination of anti-crossover activities by utilizing the Msh4?Msh5 heterodimer to block helicases. Msh4 and Msh5 have been lost from the flies Drosophila and Glossina but we identified a complex of mini-chromosome maintenance (MCM) proteins that functionally replace Msh4?Msh5. REC, an ortholog of MCM8 that is divergent in flies, interacts with MEI 217 and MEI-218, which arose from one a previously undescribed ancestral metazoan-specific MCM protein. Meiotic crossovers are reduced in Drosophila rec, mei-217, and mei-218 mutants; however, removal of the Bloom syndrome helicase ortholog restores crossovers. Thus, MCMs were co-opted into a novel complex to replace the meiotic pro-crossover function of Msh4?Msh5 in flies.

Keywords

Msh4, Msh5, MCM8, MCM9, Drosophila, Glossina

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S13435
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref21394,
  	 author = {Kathryn P. Kohl and Corbin D. Jones and Jeff  Sekelsky},
  	 title = {Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase},
  	 year = {2012},
  	 keywords = {Msh4, Msh5, MCM8, MCM9, Drosophila, Glossina},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {Science},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Generation of meiotic crossovers in many eukaryotes requires the elimination of anti-crossover activities by utilizing the Msh4?Msh5 heterodimer to block helicases. Msh4 and Msh5 have been lost from the flies Drosophila and Glossina but we identified a complex of mini-chromosome maintenance (MCM) proteins that functionally replace Msh4?Msh5. REC, an ortholog of MCM8 that is divergent in flies, interacts with MEI 217 and MEI-218, which arose from one a previously undescribed ancestral metazoan-specific MCM protein. Meiotic crossovers are reduced in Drosophila rec, mei-217, and mei-218 mutants; however, removal of the Bloom syndrome helicase ortholog restores crossovers. Thus, MCMs were co-opted into a novel complex to replace the meiotic pro-crossover function of Msh4?Msh5 in flies.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 21394
  AU  - Kohl,Kathryn P.
  AU  - Jones,Corbin D.
  AU  - Sekelsky,Jeff 
  T1  - Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase
  PY  - 2012
  KW  - Msh4
  KW  - Msh5
  KW  - MCM8
  KW  - MCM9
  KW  - Drosophila
  KW  - Glossina
  UR  - http://dx.doi.org/
  N2  - Generation of meiotic crossovers in many eukaryotes requires the elimination of anti-crossover activities by utilizing the Msh4?Msh5 heterodimer to block helicases. Msh4 and Msh5 have been lost from the flies Drosophila and Glossina but we identified a complex of mini-chromosome maintenance (MCM) proteins that functionally replace Msh4?Msh5. REC, an ortholog of MCM8 that is divergent in flies, interacts with MEI 217 and MEI-218, which arose from one a previously undescribed ancestral metazoan-specific MCM protein. Meiotic crossovers are reduced in Drosophila rec, mei-217, and mei-218 mutants; however, removal of the Bloom syndrome helicase ortholog restores crossovers. Thus, MCMs were co-opted into a novel complex to replace the meiotic pro-crossover function of Msh4?Msh5 in flies.
  L3  - 
  JF  - Science
  VL  - 
  IS  - 
  ER  -