@ARTICLE{TreeBASE2Ref21394,
author = {Kathryn P. Kohl and Corbin D. Jones and Jeff Sekelsky},
title = {Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase},
year = {2012},
keywords = {Msh4, Msh5, MCM8, MCM9, Drosophila, Glossina},
doi = {},
url = {http://},
pmid = {},
journal = {Science},
volume = {},
number = {},
pages = {},
abstract = {Generation of meiotic crossovers in many eukaryotes requires the elimination of anti-crossover activities by utilizing the Msh4?Msh5 heterodimer to block helicases. Msh4 and Msh5 have been lost from the flies Drosophila and Glossina but we identified a complex of mini-chromosome maintenance (MCM) proteins that functionally replace Msh4?Msh5. REC, an ortholog of MCM8 that is divergent in flies, interacts with MEI 217 and MEI-218, which arose from one a previously undescribed ancestral metazoan-specific MCM protein. Meiotic crossovers are reduced in Drosophila rec, mei-217, and mei-218 mutants; however, removal of the Bloom syndrome helicase ortholog restores crossovers. Thus, MCMs were co-opted into a novel complex to replace the meiotic pro-crossover function of Msh4?Msh5 in flies.}
}
Trees for Study 13435
Citation title:
"Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase".
Study name:
"Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase".
This study is part of submission 13435
(Status: Published).
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