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Citation for Study 22167

Citation title: "Evolutionary novelty through horizontal gene transfer and high-order protein assembly".

Study name: "Evolutionary novelty through horizontal gene transfer and high-order protein assembly".

This study is part of submission 22167 (Status: Published).

Citation

Nguyen T., Greig J., Khan A., Goh C., & Jedd G. 2018. Evolutionary novelty through horizontal gene transfer and high-order protein assembly. PLoS Biology, .

Authors

Nguyen T. (submitter) (+65)90569465
Greig J.
Khan A.
Goh C.
Jedd G.

Abstract

Horizontal gene transfer (HGT) can promote evolutionary adaptation by transforming a species? relationship to the environment. Most well understood cases of HGT involve the transfer of enzyme-encoding genes, where acquired and donor functions appear to remain closely related. The degree to which HGT can lead to evolutionary novelties remains unclear. Mucorales fungi sense gravity through the sedimentation of vacuolar protein crystals. Here, we identify their major constituent protein, OCTIN. Phylogenetic analysis strongly supports acquisition of octin by HGT from bacteria to the common ancestor of the Mucorales. A bacterial OCTIN forms high-order oligomers in the periplasm and disulphide bonds underlie the stability of both crystals and bacterial oligomers, suggesting that they share elements of a conserved assembly mechanism. However, estimated sedimentation velocities of bacterial OCTIN oligomers preclude any speculated role in bacterial gravity sensing. Together, out data suggest that HGT into the Mucorales allowed a dramatic increase in assembly scale and acquisition of the gravity sensing function. We conclude that HGT can lead to evolutionary novelties that emerge depending on the cellular context of protein assembly.

Keywords

Horizontal gene transfer, gravitropism, evolutionary novelty

External links

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22167
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref28050,
	 author = {Tu Anh  Nguyen and Jamie  Greig and Asif  Khan and Cara  Goh and Gregory  Jedd},
	 title = {Evolutionary novelty through horizontal gene transfer and high-order protein assembly},
	 year = {2018},
	 keywords = {Horizontal gene transfer, gravitropism, evolutionary novelty},
	 doi = {},
	 url = {http://},
	 pmid = {},
	 journal = {PLoS Biology},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {Horizontal gene transfer (HGT) can promote evolutionary adaptation by transforming a
species? relationship to the environment. Most well understood cases of HGT involve
the transfer of enzyme-encoding genes, where acquired and donor functions appear to
remain closely related. The degree to which HGT can lead to evolutionary novelties
remains unclear. Mucorales fungi sense gravity through the sedimentation of vacuolar
protein crystals. Here, we identify their major constituent protein, OCTIN. Phylogenetic analysis strongly supports acquisition of octin by HGT from bacteria to the common ancestor of the Mucorales. A bacterial OCTIN forms high-order oligomers in the periplasm and disulphide bonds underlie the stability of both crystals and bacterial oligomers, suggesting that they share elements of a conserved assembly mechanism. However, estimated sedimentation velocities of bacterial OCTIN oligomers preclude any speculated role in bacterial gravity sensing. Together, out data suggest that HGT into the Mucorales allowed a dramatic increase in assembly scale and acquisition of the gravity sensing function. We conclude that HGT can lead to evolutionary novelties that emerge depending on the cellular context of protein assembly.}
}

Show RIS reference

TY - JOUR
ID - 28050
AU - Nguyen,Tu Anh
AU - Greig,Jamie
AU - Khan,Asif
AU - Goh,Cara
AU - Jedd,Gregory
T1 - Evolutionary novelty through horizontal gene transfer and high-order protein assembly
PY - 2018
KW - Horizontal gene transfer
KW - gravitropism
KW - evolutionary novelty
UR - http://dx.doi.org/
N2 - Horizontal gene transfer (HGT) can promote evolutionary adaptation by transforming a
species? relationship to the environment. Most well understood cases of HGT involve
the transfer of enzyme-encoding genes, where acquired and donor functions appear to
remain closely related. The degree to which HGT can lead to evolutionary novelties
remains unclear. Mucorales fungi sense gravity through the sedimentation of vacuolar
protein crystals. Here, we identify their major constituent protein, OCTIN. Phylogenetic analysis strongly supports acquisition of octin by HGT from bacteria to the common ancestor of the Mucorales. A bacterial OCTIN forms high-order oligomers in the periplasm and disulphide bonds underlie the stability of both crystals and bacterial oligomers, suggesting that they share elements of a conserved assembly mechanism. However, estimated sedimentation velocities of bacterial OCTIN oligomers preclude any speculated role in bacterial gravity sensing. Together, out data suggest that HGT into the Mucorales allowed a dramatic increase in assembly scale and acquisition of the gravity sensing function. We conclude that HGT can lead to evolutionary novelties that emerge depending on the cellular context of protein assembly.
L3 -
JF - PLoS Biology
VL -
IS -
ER -