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Citation for Study 22408

Citation title: "New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores.".

Study name: "New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores.".

This study is part of submission 22408 (Status: Published).

Citation

Belahbib H., Renard E., Santini S., Jourda C., Clavery J., Borchiellini C., & Le bivic A. 2018. New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores. BMC Genomics, .

Authors

Belahbib H.
Renard E.
Santini S.
Jourda C.
Clavery J.
Borchiellini C. (submitter)
Le bivic A.

Abstract

The emergence of epithelia was the foundation of metazoan expansion. To investigate the early evolution of animal epithelia, we characterized epithelial markers such as the E-cadherin complex and the polarity complexes in all classes (Calcarea, Demospongiae, Hexactinellida, Homoscleromorpha) of sponges (phylum Porifera), in Placozoa and in Ctenophora. We found that Placozoa and most sponges possess orthologs of all essential genes encoding proteins found in bilaterian epithelial cells, as well as their conserved interaction domains. In stark contrast, we found that ctenophores lack several major polarity complex components such as the Crumbs complex and Scribble. Furthermore, the E-cadherin ctenophore ortholog exhibits a divergent cytoplasmic domain making it unlikely to be able to interact with its canonical cytoplasmic partners. These unexpected findings are interpreted in the context of the highly debated evolutionary position of Porifera and Ctenophora to challenge the current evolutionary paradigm on the emergence of epithelia.

Keywords

Metazoans, polarity complexes, E-cadherin complex

External links

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22408
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref28231,
	 author = {Hassiba  BELAHBIB and Emmanuelle  Renard and Sebastien  Santini and Cyril  Jourda and Jean Michel  Clavery and Carole  Borchiellini and Andre  Le Bivic},
	 title = {New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores.},
	 year = {2018},
	 keywords = {Metazoans, polarity complexes, E-cadherin complex},
	 doi = {},
	 url = {http://},
	 pmid = {},
	 journal = {BMC Genomics},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {The emergence of epithelia was the foundation of metazoan expansion. To investigate the early evolution of animal epithelia, we characterized epithelial markers such as the E-cadherin complex and the polarity complexes in all classes (Calcarea, Demospongiae, Hexactinellida, Homoscleromorpha) of sponges (phylum Porifera), in Placozoa and in Ctenophora. We found that Placozoa and most sponges possess orthologs of all essential genes encoding proteins found in bilaterian epithelial cells, as well as their conserved interaction domains. In stark contrast, we found that ctenophores lack several major polarity complex components such as the Crumbs complex and Scribble. Furthermore, the E-cadherin ctenophore ortholog exhibits a divergent cytoplasmic domain making it unlikely to be able to interact with its canonical cytoplasmic partners. These unexpected findings are interpreted in the context of the highly debated evolutionary position of Porifera and Ctenophora to challenge the current evolutionary paradigm on the emergence of epithelia.}
}

Show RIS reference

		TY  - JOUR
ID  - 28231
AU  - BELAHBIB,Hassiba 
AU  - Renard,Emmanuelle 
AU  - Santini,Sebastien 
AU  - Jourda,Cyril 
AU  - Clavery,Jean Michel 
AU  - Borchiellini,Carole 
AU  - Le Bivic,Andre 
T1  - New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores.
PY  - 2018
KW  - Metazoans
KW  - polarity complexes
KW  - E-cadherin complex
UR  - http://dx.doi.org/
N2  - The emergence of epithelia was the foundation of metazoan expansion. To investigate the early evolution of animal epithelia, we characterized epithelial markers such as the E-cadherin complex and the polarity complexes in all classes (Calcarea, Demospongiae, Hexactinellida, Homoscleromorpha) of sponges (phylum Porifera), in Placozoa and in Ctenophora. We found that Placozoa and most sponges possess orthologs of all essential genes encoding proteins found in bilaterian epithelial cells, as well as their conserved interaction domains. In stark contrast, we found that ctenophores lack several major polarity complex components such as the Crumbs complex and Scribble. Furthermore, the E-cadherin ctenophore ortholog exhibits a divergent cytoplasmic domain making it unlikely to be able to interact with its canonical cytoplasmic partners. These unexpected findings are interpreted in the context of the highly debated evolutionary position of Porifera and Ctenophora to challenge the current evolutionary paradigm on the emergence of epithelia.
L3  - 
JF  - BMC Genomics
VL  - 
IS  - 
ER  -