@ARTICLE{TreeBASE2Ref26509,
author = {Pieter De Maayer and Don A Cowan},
title = {Comparative genomic analysis of the flagellin glycosylation island of the Gram-positive thermophile Geobacillus},
year = {2016},
keywords = {Geobacillus; flagellin; post-translational modification; glycosylation; glycosyltransferase; pseudaminic acid},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Genomics},
volume = {},
number = {},
pages = {},
abstract = {Background: Protein glycosylation involves the post-translational attachment of sugar chains to target proteins and has been observed in all three domains of life. Post-translational glycosylation of flagellin, the main structural protein of the flagellum, is a common characteristic among many Gram-negative bacteria and Archaea. Several distinct functions have been ascribed to flagellin glycosylation, including stabilisation and maintenance of the flagellar filament, motility, surface recognition, adhesion, and virulence. However, little is known about this trait among Gram-positive bacteria.
Results: Using comparative genomic approaches the flagellin glycosylation loci of multiple strains of the Gram-positive thermophilic genus Geobacillus were identified and characterized. Eighteen of thirty-six compared strains of the genus carry these loci, which show evidence of horizontal acquisition. The Geobacillus flagellin glycosylation islands (FGIs) can be clustered into five distinct types, which are predicted to encode highly variable glycans decorated with distinct and heavily modified sugars.
Conclusions: Our comparative genomic analyses showed that, while not universal, flagellin glycosylation islands are relatively common among members of the genus Geobacillus and that the encoded flagellin glycans are highly variable. This suggests that flagellin glycosylation plays an important role in the lifestyles of members of this thermophilic genus.
}
}
Matrices for Study 20124

Citation title:
"Comparative genomic analysis of the flagellin glycosylation island of the Gram-positive thermophile Geobacillus".

Study name:
"Comparative genomic analysis of the flagellin glycosylation island of the Gram-positive thermophile Geobacillus".

This study is part of submission 20124
(Status: Published).
Matrices
ID |
Matrix Title |
Description |
Data type |
NTAX |
NCHAR |
Taxa |
|
|
|
|
M38840
|
Geobacillus Figure 3: recN nucleotide alignment |
Figure 3: recN nucleotide alignment |
Nucleic Acid |
46 |
1727 |
View Taxa
|
|
|
|
|
M38841
|
Geobacillus Figure 4: recN nucleotide alignment |
Figure 4: recN nucleotide alignment |
Nucleic Acid |
18 |
1731 |
View Taxa
|
|
|
|
|
M38846
|
Geobacillus Figure 4: Distance matrix for UPGMA |
Figure 4: Distance matrix for UPGMA |
Nucleic Acid |
18 |
18 |
View Taxa
|
|
|
|
|
M38842
|
Geobacillus Supplementary Figure S2: PseIC alignment |
Supplementary Figure S2: PseIC alignment |
Amino Acid |
15 |
759 |
View Taxa
|
|
|
|
|
M38845
|
Geobacillus Figure 4: Presence/absence matrix for UPGMA |
Figure 4: Presence/absence matrix for UPGMA |
Nucleic Acid |
18 |
90 |
View Taxa
|
|
|
|
|